CALL FOR PAPERS Cardiovascular and Cerebrovascular Aging–New Mechanisms and Insights Role of estrogens and age in flow-mediated outward remodeling of rat mesenteric resistance arteries
نویسندگان
چکیده
K. Tarhouni,* M. L. Freidja,* A. L. Guihot, E. Vessieres, L. Grimaud, B. Toutain, F. Lenfant, J. F. Arnal, L. Loufrani, and D. Henrion L’Université Nantes Angers Le Mans University and University of Angers, Angers, France; Unité Mixte de Recherche 6214, Centre National de la Recherche Scientifique, Angers, France; U1083, Institut National de la Santé et de la Recherche Médicale, Angers, France; CHU d’Angers, Angers, France; and U858, Institut National de la Santé et de la Recherche Médicale, Université Toulouse III Paul Sabatier, CHU de Toulouse, Toulouse, France
منابع مشابه
Relaxatory Effect of Gamma-Aminobutyric Acid (GABA) is Mediated by Same Pathway in Diabetic and Normal Rat Mesenteric Bed vessel
Objective(s) Diabetes related dysfunction of resistance vessels is associated with vascular occlusive diseases. Vasorelaxant agents may have a role in control of diabetic cardiovascular complications. Gamma aminobutyric acid (GABA) has demonstrated to cause vasorelaxation. The present study was designed to determine i) the vasorelaxatory effect of GABA on diabetic vessels and ii) the role of e...
متن کاملRole of estrogens and age in flow-mediated outward remodeling of rat mesenteric resistance arteries.
In resistance arteries, a chronic increase in blood flow induces hypertrophic outward remodeling. This flow-mediated remodeling (FMR) is absent in male rats aged 10 mo and more. As FMR depends on estrogens in 3-mo-old female rats, we hypothesized that it might be preserved in 12-mo-old female rats. Blood flow was increased in vivo in mesenteric resistance arteries after ligation of the side art...
متن کاملResveratrol Improved Flow-Mediated Outward Arterial Remodeling in Ovariectomized Rats with Hypertrophic Effect at High Dose
OBJECTIVES Chronic increases in blood flow in resistance arteries induce outward remodeling associated with increased wall thickness and endothelium-mediated dilatation. This remodeling is essential for collateral arteries growth following occlusion of a large artery. As estrogens have a major role in this remodeling, we hypothesized that resveratrol, described as possessing phytoestrogen prope...
متن کاملTime-Related Alteration in Flow- (Shear Stress-) Mediated Remodeling in Resistance Arteries from Spontaneously Hypertensive Rats
Hypertension is a major risk factor for cardiovascular disorders. As flow-mediated outward remodeling has a key role in postischemic revascularization, we investigated this remodeling in mesenteric resistance arteries of normotensive (WKY) and spontaneously hypertensive rats (SHRs) aged 3 to 9 months. Sequential ligation of mesenteric resistance arteries allowed modifying blood flow in vivo, th...
متن کاملDeterminants of flow-mediated outward remodeling in female rodents: respective roles of age, estrogens, and timing.
OBJECTIVE Flow (shear stress)-mediated outward remodeling (FMR) of resistance arteries is a key adaptive process allowing collateral growth after arterial occlusion but declining with age. 17-β-estradiol (E2) has a key role in this process through activation of estrogen receptor α (ERα). Thus, we investigated the impact of age and timing for estrogen efficacy on FMR. APPROACH AND RESULTS Fema...
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